This project will develop and apply advanced theoretical and computational models for two purposes. First, it will characterize how the structure of nucleic acids, proteins, and their biohybrid assemblies affects their motion through nanopores. The results will then be used to design molecules with desired pore translocation properties. The theoretical/computational project will involve close international collaborations with experimental and theoretical partner groups of the BioHYBRITE network, through which the doctoral researcher will iteratively refine models by comparing them with experiments and, finally, formulate predictions.